First Gene Edited Livestock created as Super Surrogate Washington State University US


Scientists have created the first gene-edited livestock that can serve as viable “surrogate cirrus”, males that only produce sperm carrying the genetic traits of donor animals, an advance they say is a growing global population. Can improve food production.

Research, Published In PNAS magazine, it can speed up the spread of desirable characteristics in livestock, and provide breeders in remote areas with better access to the genetic material of “elite animals” from other parts of the world.

Researchers said more precise breeding would be allowed in animals such as goats where the use of artificial insemination is difficult, the researchers said.

“With this technology, we can better disseminate desirable traits and improve the efficiency of food production. This can have a major impact on addressing food insecurity around the world,” Washington State University in the US Said John Otley, a reproductive biologist. .

“If we can deal with this genetically, it means that we have to put less water, less feed and less antibiotics into animals,” Ottley said.

Researchers used Gene editing equipment, CRISPR-Kas 9, to exclude genes specific for male fertility in animals Fetus That the surrogate be raised to become a saint.

They produced mice, pigs, goats and cattle that lacked a gene called NANOS2 that is specific for male fertility.

Researchers report that male animals become sterile but otherwise healthy, so when they found sperm-producing stem cells from other animals, they started producing sperms derived from donor’s cells, according to researchers.

Surrogate saints were confirmed to have active donor sperm, he said.

Surrogate mice gave birth to healthy offspring that carried the genes of donor mice further, with researchers mentioning that larger animals had not yet been bred.

The team is refining the stem cell transplant process before taking that next step.

Scientists have been finding a way to create surrogate cirrus for decades to overcome the limitations of selective breeding and artificial insemination, devices that require the proximity of animals or strict control of their movement, and in many cases, both.

Artificial insemination is common in dairy cattle that are often limited so their reproductive behavior is relatively easy to control, but this process is rarely used with beef cattle that need to roam freely to feed is.

For pigs, this process still requires animals because pig sperm do not survive the cold well. In goats, artificial insemination is quite challenging and may require a surgical procedure, the researchers explained.

The new technology could solve those problems because surrogates deliver genetic material in a natural way, through normal breeding, he said.

This, the researchers said, enables ranchers and shepherds to allow their animals to negotiate a boundary or area in general.

This technology has great potential to help the food supply to those places in the developing world where Irina Polojeva, a professor at Utah State University in the US, said that shepherds still depend on selective breeding to improve their stock Does matter.

Polajeva stated, “Goats are the number one source of protein in many developing countries. This technique may allow rapid spread of specific traits in goats, whether it is disease resistance, greater heat tolerance or improved meat quality, “Poljeva said.


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